Sunflower (Helianthus annuus L.) is a highly susceptible culture, especially at the time of flowering and just after flowering and according to the diseases it is one of the most endangered cultures. Moisture has an adverse effect on sunflower production, especially because of the influence on the development of diseases that can significantly reduce the yield and grain quality. Diseases vectors can be animal organisms, humans, water and air streams. The most common diseases are fungal, such as downy mildew, rust, black spots, white rot, gray spots, gray rot, brown peel and vertiginous grain. Besides fungal, diseases can also cause bacteria, viruses and parasitic flower plants. Sunflower diseases can be prevented and reppressed by different protection measures. The most important measures are preventive or agrotehnical: crop rotation, balanced fertilization, sowing the resistant hybrids and healthy seeds and sowing in the optimal time frame and recommended range. It is also possible to use mechanical (removal of diseased plants, deep plowing of infected plant residues) and chemical measures (use of fungicides).